In this work, we present two compact basis sets optimized for the calculation of specific rotation augD-3-21G and augT3-3-21G. They are obtained by combining the standard 3-21G basis set with the diffuse functions of aug-cc-pVDZ and aug-cc-pVTZ, respectively, followed by a reoptimization of the exponents of the diffuse functions. The exponent optimization is based on minimization of the root-mean-square relative error (RMSE) of the specific rotation computed at 589.3 nm (the sodium D line, [α]D) with CAM-B3LYP compared with the corresponding calculations using the full correlation-consistent basis sets. The training set comprises 21 chiral molecules with |[α]D| > 50 deg dm-1 (g/mL)-1. For augT3-3-21G, the functions with the highest angular momentum are neglected, so that augD-3-21G and augT3-3-21G are of the same size. The exponents are optimized for four common elements in chiral organic molecules (H, C, N, and O), while the original exponents are maintained for other elements. Tests are conducted on the tra calculations of specific rotation of large chiral molecules.Even 150 years after their discovery, hydroxamic acids are mainly known as the starting material for the Lossen rearrangement in textbooks.  https://www.selleckchem.com/products/Bortezomib.html  However, hydroxamic acids feature a plethora of existing and potential applications ranging from medical purposes to materials science, based on their excellent complexation properties. This underrated functional moiety can undergo a broad variety of organic transformations and possesses unique coordination properties for a large variety of metal ions, for example, Fe(III), Zn(II), Mn(II), and Cr(III). This renders it ideal for biomedical applications in the field of metal-associated diseases or the inhibition of metalloenzymes, as well as for the separation of metals. Considering their chemical stability and reactivity, their biological origin and both medical and industrial applications, this Perspective aims at highlighting hydroxamic acids as highly promising chelators in the fields of both medical and materials science. Furthermore, the state of the art in combining hydroxamic acids with a variety of polymer structures is discussed and a perspective regarding their vast potential at the interface of bioinorganic and polymer chemistry is given.Sea urchin embryo assay was used to assess general toxicity at four wastewater treatment plant effluents of Biscay (Gorliz, Mungia, Gernika, and Galindo), and within the tested range, all the extracts showed embryo growth inhibition and skeleton malformation activities with EC50 values, in relative enrichment factor units, between 1.1-16.8 and 1.1-8.8, respectively. To identify the causative compounds, effect-directed analysis was successfully applied for the first time using a sea urchin embryo test to the secondary treatment of the Galindo effluent. To this end, two subsequent fractionation steps were performed using C18 (21 fractions) and aminopropyl columns (15 fractions). By this fractionation, the number of features detected by LC-HRMS in the raw sample was drastically reduced from 1500 to 9, and among them, two pesticides (mexacarbate, 17 ng/L, and fenpropidin, 23 ng/L), two antidepressants (amitriptyline, 304 ng/L, and paroxetine, 26 ng/L), and two anthelmintic agents (mebendazole, 65 ng/L, and albendazole, 48 ng/L) could be identified in the two toxic fractions. The artificial mixture of the identified six compounds could explain 79% of the observed effect, with albendazole and paroxetine as the predominant contributors (49% and 49%, respectively) affecting the sea urchin embryogenesis activity.Surface functional groups and graphitic carbons make up the electroactive components of pyrogenic carbon. The role of pyrogenic carbon with different contents of electroactive components in mediating electron transfer in biochemical reactions has not been systematically studied. Here, we determined the electron exchange capacity (EEC) of pyrogenic carbon to be 0.067-0.120 mmol e-·(g of pyrogenic carbon)-1, and the maximum electrical conductivity (EC) was 4.85 S·cm-1. Nitrobenzene was simultaneously reduced in both the liquid and sorbed phases by Shewanella oneidensis MR-1 in the presence of pyrogenic carbon. Pyrogenic carbon did not affect the aqueous nitrobenzene reduction, and the reduction of sorbed nitrobenzene was much slower than that of the aqueous species. Enhancing contents of oxygenated functional moieties in pyrogenic carbon with HNO3 oxidation elevated bioreduction rates of the aqueous and sorbed species. Anthraquinone groups were deemed as the most likely oxygenated functional redox compounds on the basis of both voltammetric curve tests and spectroscopic analysis. The reactivity of pyrogenic carbon in mediating the reduction of sorbed nitrobenzene was positively correlated with its EC, which was demonstrated to be related to condensed aromatic structures. This work elucidates the mechanism for pyrogenic carbon-mediated biotransformation of nitrobenzene and helps properly evaluate the role of pyrogenic carbon in biogeochemical redox processes happening in nature.Urban concentrations of black carbon (BC) and other primary pollutants vary on small spatial scales ( less then 100m). Mobile air pollution measurements can provide information on fine-scale spatial variation, thereby informing exposure assessment and mitigation efforts. However, the temporal sparsity of these measurements presents a challenge for estimating representative long-term concentrations. We evaluate the capabilities of mobile monitoring in the represention of time-stable spatial patterns by comparing against a large set of continuous fixed-site measurements from a sampling campaign in West Oakland, California. Custom-built, low-cost aerosol black carbon detectors (ABCDs) provided 100 days of continuous measurements at 97 near-road and 3 background fixed sites during summer 2017; two concurrently operated mobile laboratories collected over 300 h of in-motion measurements using a photoacoustic extinctiometer. The spatial coverage from mobile monitoring reveals patterns missed by the fixed-site network. Time-integrated measurements from mobile lab visits to fixed-site monitors reveal modest correlation (spatial R2 = 0.51) with medians of full daytime fixed-site measurements. Aggregation of mobile monitoring data in space and time can mitigate high levels of uncertainty associated with measurements at precise locations or points in time. However, concentrations estimated by mobile monitoring show a loss of spatial fidelity at spatial aggregations greater than 100 m.