https://www.selleckchem.com/Proteasome.html At the end of June accesses to ED and admissions to hospital ward are still lower than usual. Fear of contagion and appeals not to use ED directly by Covid-19 patients may have discouraged access also for pressing health need. Fear of contagion and appeals not to use ED directly by Covid-19 patients may have discouraged access also for pressing health need. To evaluate the therapeutic responsiveness of office-based salivary gland ductal irrigation in patients with chronic sialoadenitis. Between August 2017 and April 2019, 55 patients comprising the following three disease groups were enrolled Sjogren's syndrome 39 patients; postradiotherapy sialoadenitis ten patients; and post-RAI sialoadenitis six patients. Quantitative salivary scintigraphy was recorded, and a formulated questionnaire including the Summated Xerostomia Inventory was utilized to assess acute/chronic symptoms. All patients received at least three serial salivary gland ductal irrigations with a one-month interval in our outpatient department. The general response rates for each disease groups are as follows Sjogren's syndrome 61.5% (24/39); postradiotherapy 60% (6/10); and post-RAI 83.3% (5/6). Among the patients with Sjogren's syndrome, the parotid scintigraphic T showed a significant positive correlation with the responsiveness of salivary irrigation (P = 0.046), whereas the treatment tended to be irresponsive in patients who previously took medicine for their related discomfort (P = 0.009). In the postradiotherapy and post-RAI groups, no significant factors were found to be associated with the responsiveness of irrigation. Simple salivary ductal irrigation without complex equipment can be performed as an outpatient procedure to alleviate glandular swelling or xerostomia in patients with Sjogren's syndrome, postradiotherapy sialoadenitis or post-RAI sialoadenitis, and it can be considered an alternative management approach for patients refractory to conven