Ga-68 is a positron-emitting nuclide that has recently achieved clinical acceptance as the diagnostic radionuclide in PET tracers used for theranostic studies of Lu-177 labeled therapeutic drugs due to the ease of access provided by Ge-68/Ga-68 generators. An alternative method of production currently being explored uses accelerators to form Ga-68 directly. This review of Ga-68 production strategies discusses available accelerator targetry at a range of beam energies and intensities, the many radiochemical separation techniques available to isolate Ga-68 from irradiated targets, isotopically enriched target material recovery, and the implications of these techniques for downstream radiolabeling applications.
  Reuse of waste materials present in the technosphere, such as the metal mining tailings is becoming a more economical and energy-efficient method for obtaining the raw materials than the classical mining. Number of patents are presenting methods for tailings recycling, often in construction industry and metallurgy. At the same time, world market for metallic nanomaterials is rapidly increasing with numerous new applications and these two subjects should be connected.
 
  Paper presents the hypothesis that fine sludge from the metal mining tailings could be dominant source of the raw material for the nanotechnology. The idea is based on the fact that most of the usual publications present methodologies for synthesis of nanomaterials only from high-quality chemicals which is often expensive and unsustainable. Proposition here says, that it would be more economical to use the tailings as one of the technospheric wastes, directly by extracting the metal ions, selectively precipitating their cations and subsequently using them in nanotechnologies. Arguments are given by cross-comparison of the literature and patents on iron, bauxite, lead/zinc, copper, tailings and also the extraction of rare earth elements from tailing resources.
 
  Metal mining tailings are shown to be an emerging subject in various research papers and patents together with other secondary raw materials.
 
  Use of the metal mining tailings as the resources in nanotechnology, is a large energy-saving potential. Taking advantage of this readily available technospheric waste which contains mostly micrometer particles, should contribute also to the zero-metal waste goals.
 Use of the metal mining tailings as the resources in nanotechnology, is a large energy-saving potential. Taking advantage of this readily available technospheric waste which contains mostly micrometer particles, should contribute also to the zero-metal waste goals.
  Nanosuspensions are colloidal systems consisting of pure drug and stabilizers, without matrix or lyophilized into a solid matrix. Nanosuspensions improve the solubility of the drug both in the aqueous and organic phases. Nanosuspensions are also known as brick dust molecules, as they increase the dissolution of a system and improve absorption.
 
  Extensive information related to nanosuspensions and its associated patents were collected using PubMed and Google Scholar.
 
  Over the last decade nanosuspensions have attracted tremendous interest in pharmaceutical research. It provides unique features including, improved solubility, high drug loading capacity, and passive targeting. These particles are costeffective, simple, and have lesser side effects with minimal dose requirements. However, the stability of nanosuspensions still warrants attention.
 
  Nanosuspensions plays a vital role in handling the numerous drug entities with difficult physico-chemical characteristics such as solubility and can further aid with a range of routes that include nasal, transdermal, occular, parenteral, pulmonary etc. This review highlights the relevance of nanosuspensions in achieving safe, effective and targeted drug delivery.
 Nanosuspensions plays a vital role in handling the numerous drug entities with difficult physico-chemical characteristics such as solubility and can further aid with a range of routes that include nasal, transdermal, occular, parenteral, pulmonary etc. This review highlights the relevance of nanosuspensions in achieving safe, effective and targeted drug delivery.Buckwheat is a gluten-free pseudo-cereal that is a part of the Polygonaceae family. Grain of buckwheat is a highly healthy component of food and has been found to have a broad variety of beneficial effects. It is cultivated as grain in a popular buckwheat (Fagopyrum esculentum) is a secondary significance in many countries. It contains certain high-level nutritionally beneficial components and can have other characteristics as functional food. Buckwheat protein is of outstanding quality and, unlike popular cereals, is rich in critical amino acid lysine. Health benefits of this plants include reducing plasma cholesterol level, anti-inflammatory, neuroprotective, anti-cancer, anti-diabetic effects and enhancing hypertension symptoms. Buckwheat is also used in gluten free diet in people with celiac disease and in the alleviation of other common disease. It has also been recognized that buckwheat has a prebiotic and antioxidant activity. The key purpose of this review article is to analyze advance work on the health benefits of buckwheat, concentrating on the particular function of its bioactive compounds and the process by which such effects are carried out.While facing potentially high morbidity from COVID-19 without known effective therapies, the off-label use of several non-specific drugs has been advocated, including re-purposed anti-virals (e.g.  https://www.selleckchem.com/products/wnt-c59-c59.html  remdesivir or the lopinavir/ritonavir combination), biologic agents (e.g. tocilizumab), and antimalarial drugs such as chloroquine and hydroxychloroquine, in association with or without azithromycin. Data regarding the effectiveness of these drugs in treating COVID-19 has been shown in some trials and clinical settings, but further randomised controlled trials are still being carried out. One of the main concerns regarding their widespread use however, are their possible effects on the QT interval and their arrhythmogenic potential. Some of this drugs have been in fact associated to QT prolongation and Torsades de Point, a potentially lethal ventricular arrhythmia. Aim of this review is to highlight the magnitude of this problem, to quickly refresh clinically impacting cornerstones of QT interval and TdP pathophysiology, to summarize the available evidence regarding the QT and arrhythmia impact of drugs used in different clinical settings in COVID-19 patients, and to help the physician dealing with the knowledge needed in the everyday clinical duties in case of doubts regarding QT-induced arrhythmias in this time of emergency.