https://www.selleckchem.com/products/pitstop-2.html 113; 95% CI 0.674-1.837). We noted a potential toward greater complete ST-segment resolution in RIC patients compared with IPC patients (odds ratio (OR) = 0.821; 95% CI 0.166-4.051). No significant difference existed in all-cause mortality (OR = 2.211; 95% CI 0.845-5.784), Target vessel revascularization (TVR) (OR = 0.045; 95% CI 0.001-.662) or re-infarction (OR = 1.763; 95% CI 0.741-4.193). This meta-analysis suggested RIC was correlated with significantly smaller infarction size compared to IPC. No significant superiority between RIC and IPC has been observed in this study on cSTR incidence, mortality and re-infarction or TVR. This meta-analysis suggested RIC was correlated with significantly smaller infarction size compared to IPC. No significant superiority between RIC and IPC has been observed in this study on cSTR incidence, mortality and re-infarction or TVR. Treatment of chronic total occlusions (CTO) despite improvement in techniques and results over the last years still seems to be limited to a small number of centres and operators. Application of the hybrid strategy may support further spread of CTO percutaneous coronary intervention (PCI) and increase procedural success rates. Our single-centre prospective ongoing registry aims to provide details and results of recanalizations of coronary CTO performed according to the hybrid algorithm in a series of consecutive patients. Between January 2015 and September 2019 the clinical and procedural data of CTO PCI procedures on consecutive patients were collected. Lesion complexity was assessed according to the Multicenter CTO Registry of Japan (J-CTO) score 0 - easy, 1 - intermediate, 2 - difficult, ≥ 3 - very difficult and PROGRESS score. Strategies applied were classified as antegrade wire escalation (AWE), antegrade dissection and re-entry (ADR), retrograde wire escalation (RWE) and retrograde dissection and patient died due to acute kidney injury complicatio