https://www.selleckchem.com/products/gsk2334470.html Scanning electron microscopy is a powerful tool for nanoscale imaging of organic and inorganic materials. An important metric for characterizing the limits of performance of these microscopes is the Detective Quantum Efficiency (DQE), which measures the fraction of emitted secondary electrons (SEs) that are detected by the SE detector. However, common techniques for measuring DQE approximate the SE emission process to be Poisson distributed, which can lead to incorrect DQE values. In this paper, we introduce a technique for measuring DQE in which we directly count the mean number of secondary electrons detected from a sample using image histograms. This technique does not assume Poisson distribution of SEs and makes it possible to accurately measure DQE for a wider range of imaging conditions. As a demonstration of our technique, we map the variation of DQE as a function of working distance in the microscope. Despite trial evidence, high intensity statins are underutilized in routine clinical practice. This study sought to assess the individual and joint contributions of the TRS2P score as a measure of residual risk and LDL-C levels to benefits from further LDL-C lowering in the TNT trial. A total of 9980 patients were divided into 4 groups based on TRS2P and LDL-C at baseline <median TRS2P and <median LDL-C (group 1), <median TRS2P and ≥median LDL-C (group 2), ≥median TRS2P and <median LDL-C (group 3), ≥median TRS2P and ≥median LDL-C (group 4). The effect of atorvastatin 80mg vs. 10mg on the risk of any cardiovascular event was assessed among the groups. Percentage reductions in LDL-C with atorvastatin 80mg were consistent across groups, whereas absolute reductions were approximately 11mg/dL greater when LDL-C was ≥median. Despite atorvastatin 10mg, either TRS2P≥median or LDL-C≥median were associated with more events and highest when both were ≥median (groups 1-4; 21.5%, 28.1%, 36.3%, and 40.5%, respectively; p-t