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https://www.selleckchem.com/products/KU-60019.html It did not, which indicates that the influence on group estradiol levels may be specific to cues from the queen. These queen cues may be behavioral in nature, as we found that queens were less aggressive during pregnancy, which prior work has suggested may relax reproductive suppression of subordinates. Yet levels of queen aggression alone were not associated, or were weakly associated, with their colony's estradiol levels, though our sample size examining this particular relationship was low. This is suggestive that additional queen cues of reproductive status, beyond just aggression, may be relevant in influencing the subordinate hormonal change, or that the relationship between aggression and colony estradiol levels is more subtle and would need to be elucidated with a larger sample size. These results have implications for how cooperative breeders coordinate reproduction and alloparental care, and how social cues can influence individual and group physiology. Psychiatric patients are perceived to be especially vulnerable during a pandemic as it increases stress and uncertainty. Several current publications have considered Obsessive-Compulsive Disorder (OCD) patients to be particularly vulnerable during the Coronavirus Disease 2019 (COVID-19), and clinicians were advised to adjust treatments accordingly. The purpose of this study was to evaluate the two- and six-month impacts of COVID-19 on the symptom severity of OCD patients. A cohort of OCD patients, actively treated with Exposure and Response Prevention [ERP] combined with pharmacological treatment, was evaluated as part of their regular psychiatric assessment twice 113 patients were evaluated at their two-month follow-up, and 90 patients (from that cohort), were evaluated at their six-month follow up. Eighty-four percent of the patients at the two-month follow-up and 96% of the patients at the six-month follow-up did not show OC symptom deterioration. The re

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