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in English, French Les allergies alimentaires de l’enfant sont un fardeau de santé publique important dans les pays industrialisés. Leur prévalence augmente également dans les pays en croissance, témoignant de l’impact d’une alimentation moderne globalisée qui met l’humanité au défi de s’adapter à un stress allergénique inédit. La compréhension des multiples mécanismes impliqués dans l’émergence de ces allergies a largement progressé depuis deux décennies. Sur le plan thérapeutique, le régime d’éviction a montré ses limites et ses risques chez des individus en croissance. La nutrition personnalisée représente un champ d’investigations, prometteur en innovations thérapeutiques.in English, French La prise en charge des patientes à haut risque d’accouchement prématuré entre 23 et 26 semaines d’aménorrhée (SA) doit être faite par une équipe périnatale expérimentée. Afin d’améliorer la prise en charge des couples dans cette situation particulièrement difficile, nous avons élaboré un protocole commun entre obstétriciens et néonatologues. Cette réflexion vise à uniformiser les pratiques au sein du CHUV et à assurer aux couples des soins personnalisés. https://www.selleckchem.com/products/jtc-801.html Le pronostic fœtal ne dépend pas uniquement de l’âge gestationnel mais d’un ensemble de facteurs dont il est important de tenir compte dans la discussion avec les parents. Ainsi la corticothérapie, facteur pronostique majeur, doit être réalisée le plus rapidement possible en cas de menace sévère. L’injection ne doit pas être différée par la réflexion des couples sur les soins néonataux.in English, French La prise en charge prénatale permet d’anticiper les complications afin de minimiser les risques au moment de l’accouchement et de la naissance. En Suisse, elle s’organise autour d’une collaboration du réseau libéral et hospitalier avec une hiérarchisation du niveau de risque de la grossesse pour le suivi. La structure de la prise en charge périnatale doit être construite de façon à identifier les risques obligeant les professionnels à sortir de la voie physiologique classique pour une escalade thérapeutique anticipative, appropriée selon les niveaux de risque. Une collaboration efficace autour du couple mère-enfant (ou même de la famille) dépend donc d’une plateforme d’interaction multidisciplinaire privilégiée dans laquelle la communication interprofessionnelle, et particulièrement sage-femme-obstétricien-néonatologue, est essentielle.BACKGROUND In multiple sclerosis (MS), insufficient blood supply might worsen energy deficiency of the brain tissue. Thus, cerebrovascular reactivity (CVR), which is the capacity of cerebral circulation to match blood supply to metabolic demand, might be important in MS pathology. OBJECTIVES The objective of this study was to investigate the relationship of CVR to disease activity and neuroimaging markers of disease progression in patients with MS. MATERIAL AND METHODS In 43 patients with relapsing remitting MS (RRMS) in clinical remission, 30 patients with a relapse of MS and 30 healthy controls, we measured CVR with transcranial Doppler as a relative change in flow velocity after breath-holding (breath-holding index) and voluntary hyperventilation (hyperventilation index). All patients in remission underwent brain magnetic resonance imaging at baseline and 33 underwent repeated imaging after 12 months, with various brain volume measurements taken. RESULTS Cerebrovascular reactivity indices did not differ between patients in remission, patients with a relapse and controls. In patients in remission, CVR did not differ between those with or without contrast-enhancing lesions. In patients with a relapse, glucocorticoids significantly reduced both CVR indices. Cerebrovascular reactivity was not related to brain volume, white matter lesion volume, percent brain volume change, and the change in total white matter lesion volume. CONCLUSIONS In RRMS, CVR appeared normal and unrelated to disease activity. There was no substantial association of CVR to brain atrophy and accumulation of white matter lesions.BACKGROUND Childhood acute lymphoblastic leukemia (ALL) survivors are at an increased risk of cardiovascular disease development. It is believed that in the general population, this risk can be predicted with carotid intima-media thickness (CIMT) measurement. OBJECTIVES The objective of this study was to assess CIMT and to investigate the effects of blood pressure (BP) and lipid profile values on CIMT in childhood ALL survivors. MATERIAL AND METHODS The study group comprised 81 childhood ALL survivors aged 5-25 years. The control group consisted of 52 ageand sex-comparable healthy children. Carotid intima-media thickness measurement, 24-hour BP monitoring and lipid profiles were evaluated in patients and controls. RESULTS Despite significantly higher proportion of subjects with arterial hypertension (AH) (30/81 vs 10/52; p = 0.0315), the mean values of CIMT were not statistically different in childhood ALL survivors as compared to controls (0.4303 ±0.03 vs 0.4291 ±0.03; p = 0.81 and 1.096 ±0.74 vs 1.027 ±0.55ed to predict cardiovascular risk in childhood ALL survivors at the early stage of the follow-up.BACKGROUND Rotational atherectomy (RA) used in elderly patients treated with percutaneous coronary interventions (PCI) could enable revascularization or the omission of cardiac surgery. Knowledge about factors affecting the prognosis may improve the results of treatment. OBJECTIVES We aimed to assess the relationship of gender and age with long-term clinical outcomes expressed as major adverse cardiac and cerebrovascular events (MACCEs). MATERIAL AND METHODS The study included 97 consecutive patients treated with PCI and RA at the mean age of 71. The study group contained 73.2% men and 26.8% women, 36.1% of patients older than 75 and 63.9% younger than 75. The mean time of follow-up was 695.3 ±560.9 days. The rate of MACCEs (deaths, myocardial infarctions (MIs), reinterventions, coronary artery by-pass surgeries, or cerebral strokes (CSs)/transient ischemic attacks (TIAs)) in the overall group of patients was calculated at 33.7%. RESULTS The comparison of Kaplan-Meier survival curves did not depict significant differences in the frequency of MACCEs for age (p = 0.
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