Yam Code
Sign up
Login
New paste
Home
Trending
Archive
English
English
Tiếng Việt
भारत
Sign up
Login
New Paste
Browse
More interestingly, SP94-PS-DOX under 10 mg DOX/kg induced far better therapeutic efficacy toward orthotopic SMMC-7721 HCC models than PS-DOX and Lipo-DOX controls giving substantial survival benefits and little adverse effects. The remarkable specificity and therapeutic outcomes lend SP94-PS-DOX promising for targeted HCC therapy.In recent times, phytochemicals encapsulated or conjugated with nanocarriers for delivery to the specific sites have gained considerable research interest. Phytochemicals are mostly plant secondary metabolites which reported to be beneficial for human health and in disease theraphy. However, these compound are large size and polar nature of these compounds, make it difficult to cross the blood-brain barrier (BBB), endothelial lining of blood vessels, gastrointestinal tract and mucosa. Moreover, they are enzymatically degraded in the gastrointestinal tract. Therefore, encapsulation or conjugation of these compounds with nanocrriers could be an alternate way to enhance their bioefficacy by influencing their gastrointestinal stability, rate of absorption and dispersion. This review presents an overview of nanocarriers alternatives which improves therapeutic value and avoid toxicity, by releasing bioactive compounds specifically at target tissues with enhanced stability and bioavailability. Future investigations may emphasize on deciphering the structural changes in nanocarriers during digestion and absorption, the difference between in-vitro and in-vivo digestion simulations, and impact of nanocarriers on the metabolism of phytochemicals.Locoregional failure remains a therapeutic challenge in oropharyngeal squamous cell carcinoma (OPSCC). We aimed to devise novel objective imaging biomarkers for prediction of locoregional progression in HPV-associated OPSCC. Following manual lesion delineation, 1037 PET and 1037 CT radiomic features were extracted from each primary tumor and metastatic cervical lymph node on baseline PET/CT scans. Applying random forest machine-learning algorithms, we generated radiomic models for censoring-aware locoregional progression prognostication (evaluated by Harrell's C-index) and risk stratification (evaluated in Kaplan-Meier analysis). A total of 190 patients were included; an optimized model yielded a median (interquartile range) C-index of 0.76 (0.66-0.81; p = 0.01) in prognostication of locoregional progression, using combined PET/CT radiomic features from primary tumors. Radiomics-based risk stratification reliably identified patients at risk for locoregional progression within 2-, 3-, 4-, and 5-year follow-up intervals, with log-rank p-values of p = 0.003, p = 0.001, p = 0.02, p = 0.006 in Kaplan-Meier analysis, respectively. Our results suggest PET/CT radiomic biomarkers can predict post-radiotherapy locoregional progression in HPV-associated OPSCC. Pending validation in large, independent cohorts, such objective biomarkers may improve patient selection for treatment de-intensification trials in this prognostically favorable OPSCC entity, and eventually facilitate personalized therapy.The growth in the number of industries aiming at more sustainable business processes is driving the use of the European Waste Catalogue (EWC). For example, the identification of industrial symbiosis opportunities, in which a user-generated item description has to be annotated with exactly one EWC tag from an a priori defined tag ontology. This study aims to help researchers understand the perils of the EWC when building a recommender system based on natural language processing techniques. We experiment with semantic enhancement (an EWC thesaurus) and the linguistic contexts of words (learned by Word2vec) for detecting term vector similarity in addition to direct term matching algorithms, which often fail to detect an identical term in the short text generated by users. Our in-depth analysis provides an insight into why the different recommenders were unable to generate a correct annotation and motivates a discussion on the current design of the EWC system.Systematic utilization of carbonated Mg-Al layered double hydroxide (LDH) nanosheets for methyl orange removal was investigated with respect to particle dimensions. LDHs with the smallest dimensions were carefully synthesized to have a small lateral size as well as high dispersibility. https://www.selleckchem.com/products/VX-770.html The other particles, with medium and large sizes, were prepared by hydrothermal treatment and urea hydrolysis to have larger sizes and higher crystallinity. According to kinetics and isotherm analyses, the smallest LDH showed efficient adsorption of methyl orange (1250 mg/g-LDH), which was remarkably higher than the adsorption by the other LDHs with larger lateral sizes. Unlike the larger lateral-sized LDHs, the small ones were shown to utilize all accessible adsorption sites on the nanosheets, generating nanoconfinement of methyl orange molecules. Transmission electron microscopy (TEM) and powder X-ray diffraction (PXRD) patterns indicated that the LDHs with lateral dimensions of ~40 nm fully utilized interlayer nanospace. Monte Carlo simulation suggested that the intercalated methyl orange was stabilized not only through electrostatic interactions with the LDH layer but also by π-π stacking between the methyl orange molecules, which is thought to be the driving force for replacement of carbonate anions.Among the input data of the watershed model for simulating changes of flowrate in the watershed, weather input data, especially input data related to rainfall, are the most important. Therefore, it is important to ensure the accuracy of rainfall input data to increase the accuracy of the watershed model results. Securing rainfall measurements with finer spatial and temporal resolutions is important in predicting flowrate variations at a sub-catchment, especially as they relate to global and local climate changes in weather conditions such as rainfall depth, rainfall intensity, etc. In this study, adjusted radar-rainfall estimates were suggested as alternative input data for watershed modeling. Through a statistical analysis of the representativeness of a ground rainfall measurement (10 km × 10 km grid), the necessity of radar-rainfall estimates (2 km × 2 km grid) was identified. By applying calibration factors to initial radar-rainfall estimates and comparing adjusted radar-rainfall estimates with ground rainfall measurements, it was proven that adjusted radar-rainfall estimates could be used as input data for watershed simulations (NSE > 0.
Paste Settings
Paste Title :
[Optional]
Paste Folder :
[Optional]
Select
Syntax Highlighting :
[Optional]
Select
Markup
CSS
JavaScript
Bash
C
C#
C++
Java
JSON
Lua
Plaintext
C-like
ABAP
ActionScript
Ada
Apache Configuration
APL
AppleScript
Arduino
ARFF
AsciiDoc
6502 Assembly
ASP.NET (C#)
AutoHotKey
AutoIt
Basic
Batch
Bison
Brainfuck
Bro
CoffeeScript
Clojure
Crystal
Content-Security-Policy
CSS Extras
D
Dart
Diff
Django/Jinja2
Docker
Eiffel
Elixir
Elm
ERB
Erlang
F#
Flow
Fortran
GEDCOM
Gherkin
Git
GLSL
GameMaker Language
Go
GraphQL
Groovy
Haml
Handlebars
Haskell
Haxe
HTTP
HTTP Public-Key-Pins
HTTP Strict-Transport-Security
IchigoJam
Icon
Inform 7
INI
IO
J
Jolie
Julia
Keyman
Kotlin
LaTeX
Less
Liquid
Lisp
LiveScript
LOLCODE
Makefile
Markdown
Markup templating
MATLAB
MEL
Mizar
Monkey
N4JS
NASM
nginx
Nim
Nix
NSIS
Objective-C
OCaml
OpenCL
Oz
PARI/GP
Parser
Pascal
Perl
PHP
PHP Extras
PL/SQL
PowerShell
Processing
Prolog
.properties
Protocol Buffers
Pug
Puppet
Pure
Python
Q (kdb+ database)
Qore
R
React JSX
React TSX
Ren'py
Reason
reST (reStructuredText)
Rip
Roboconf
Ruby
Rust
SAS
Sass (Sass)
Sass (Scss)
Scala
Scheme
Smalltalk
Smarty
SQL
Soy (Closure Template)
Stylus
Swift
TAP
Tcl
Textile
Template Toolkit 2
Twig
TypeScript
VB.Net
Velocity
Verilog
VHDL
vim
Visual Basic
WebAssembly
Wiki markup
Xeora
Xojo (REALbasic)
XQuery
YAML
HTML
Paste Expiration :
[Optional]
Never
Self Destroy
10 Minutes
1 Hour
1 Day
1 Week
2 Weeks
1 Month
6 Months
1 Year
Paste Status :
[Optional]
Public
Unlisted
Private (members only)
Password :
[Optional]
Description:
[Optional]
Tags:
[Optional]
Encrypt Paste
(
?
)
Create New Paste
You are currently not logged in, this means you can not edit or delete anything you paste.
Sign Up
or
Login
Site Languages
×
English
Tiếng Việt
भारत